New Discovery of Covid-19 Natural-Based Antivirus Herbal Supplement Products from Pinang Yaki (Areca vestiaria) Extract by Untargeted Metabolomic Profiling

Background: Pinang yaki has bioactive compounds that have potential as a new herbal supplement. A better understanding of the pinang using untargeted metabolomic profiling studies will provide clearer insight into health benefits and in particular its for therapy prevention Covid-19. Methods: Fresh samples (Areca vestiaria) are obtained from forests North Sulawesi Province, Indonesia. Samples were used metabolomics analysis by UPLC-MS. Results: Based on an study yaki, 2504 ESI- 2645 ESI+ successfully obtained. After analysis, 356 543 identified successfully. Major Alpha-Chlorohydrin (PubChem ID: 7290) Tagatose 439312) found ESI-. Discussion: The Top 10 metabolites extract (ESI+) juga been indicated preventing SARS Cov2 infection exhibited good neuroprotective immunity. Benzothiazole 7222), L-Isoleucine 6306), D-Glucono-Delta-Lactone 736), Diethylpyrocarbonate 3051), Bis(2-Ethylhexyl) amine 7791), Cinnamic Acid 444539), Trigonelline 5570) also had effects antiviral, anti-inflammatory, anti-Covid19. Conclusion: Untargeted showed many contained extract. The top explored their anti-Covid19 supplement products.